分类： 核科学技术 >> 核材料与工艺技术 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要： In this paper, the safety and efficacy of 131I-labeled mouse/human chimeric monoclonal antibody (131I-chTNT)-mediated radioimmunotherapy are evaluated because the patients have non-uptaking 131I pulmonary metastases from differentiated thyroid carcinoma (DTC). The 16 patients were injected intravenously by 29.63.7 MBqkg1 using 131I-chTNT. The chest computer tomography was performed before treatment, as well as 28 and 70 days after treatment. Responses and safety were assessed during the treatment. The results show that the 131I-chTNT infusion was well tolerated with the 12.5% complete response, 18.8% partial response, 25.0% progressive disease, and the 43.8% stable disease, indicating that most treatment-related adverse effects are mild transient and reversible. The 131I-chTNT is promising for patients with non-uptaking the 131I pulmonary metastases from DTC.
分类： 核科学技术 >> 核材料与工艺技术 提交时间： 2023-06-18 合作期刊: 《Nuclear Science and Techniques》
摘要： In recent years, several RGD (Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin v3, demonstrating its feasibility in tumor diagnosis. In this paper, we evaluated the 99mTc-3P4-RGD2 single photon emission computed tomography/computerized tomography (SPECT/CT) in patients suffering from space occupying disease of esophagus. 40 patients (34 males and 6 female; mean age: 58.3 years) with a suspected space occupying lesion of esophagus were included, thus finally obtaining their definite pathologic diagnosis (malignant, n=32; benign, n=8). All patients underwent endoscopic, barium esophagography and SPECT/CT imaging preoperatively. The chest SPECT was performed at 4 h after administration of 99mTc-3P4-RGD2 with a dose of 939118 MBq. The diagnosis precision, sensitivity and specificity among these methods were compared. The relationship between radioactive uptake and clinical pathological stage of esophageal carcinoma was discussed by calculating the tumor to normal esophagus (T/N). Meanwhile, the integrin v3 expression was assessed immunohistochemically in postoperative esophageal tissues. 31 patients were diagnosed as esophageal carcinoma; and 1, leiomyosarcoma; and 6. leimyoma; and 2, esophageal tuberculosis. The accuracy, sensitivity and specificity of barium esophagography, endoscopic and SPECT/CT imaging are 92.5/93.8/87.5%, 97.5/96.9/100%, and 90/90.6/87.5%, respectively. Abnormal accumulation of radiotracer in 29 malignant lesions is observed. The SPECT/CT imaging displayed the region of radioactive uptake and lesions matched extremely with the T/N ratio from 1.31 to 2.79 (mean 2.04). A case with pulmonary metastases and a case with mediastinal lymph node metastases were found which were missed by barium esophagography and endoscopic. The 99mTc-3P4-RGD2 uptake of the esophageal carcinoma masses had no relevance to the tumor pathologic classification (P>0.05). There was a significant positive correlation between T/N ratio and positive cell percentage of integrin v3 (r=0.976), demonstrating the certain clinical potential in the diagnosis of esophageal carcinoma.
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